Name | 3-(Methylthio)propionic acid |
Synonyms | 4-Thiapentanoic acid 3-METHYLTHIO PROPIONATE 3-Methythiopropionic acid 3-METHYTHIOPROPIONIC ACID 3-METHYLTHIOPROPIONIC ACID 3-Methylthiopropionic Acid 3-(Methylthio)propionic acid 3-(methylsulfanyl)propanoate 3-METHYLMERCAPTOPROPIONIC ACID Propanoic acid, 3-(methylthio)- Propionic acid, 3-(methylthio)- 3-(Methylsulfanyl)propanoic acid |
CAS | 646-01-5 |
EINECS | 211-460-9 |
InChI | InChI=1/C4H8O2S/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 |
Molecular Formula | C4H8O2S |
Molar Mass | 120.17 |
Density | 1.160 |
Melting Point | 16°C |
Boling Point | 130°C 2mm |
Flash Point | 130°C/15mm |
Vapor Presure | 0.00741mmHg at 25°C |
Appearance | Transparent liquid |
Color | White or Colorless to Light yellow |
BRN | 1743054 |
pKa | 4.29±0.10(Predicted) |
Storage Condition | -20℃ |
Refractive Index | 1.4884 |
MDL | MFCD00059635 |
In vitro study | Methionine has consistently been shown to be the most toxic amino acid in experiments devised to assess the relative toxicity of dietary amino acids. 3-methylthiopropionate is an intermediate in methionine catabolism in rat and monkey liver in vitro . This pathway appears to account for a major portion of methionine oxidation in vitro . Cultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The first intermediate in the pathway may be the keto acid, which is then oxidatively decarboxylated to 3-methylthiopropionic acid. The purified 3-MTPA has antifungal activity in assays using F. oxysporum as a model fungus. Daily measurements of shoot and root length shows severe inhibition of seed germination and root and shoot development at concentrations above 12mg for partially purified extracts. 3-methylthiopropionic acid ethyl ester possesses potential anticarcinogenic properties by inducing differentiation in well-differentiated colon cancer cells. Treatment of RCM-1 cells for 4 days with 3-methylthiopropionic acid ethyl ester between the doses of 0.25 and 2 mM progressively increases the percent area occupied by duct structures relative to the control, and also induces an increase in the number and the maximum diameter of the ducts in each culture plate. |
Risk Codes | 34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | 3265 |
HS Code | 29309090 |
Hazard Class | 8 |
Packing Group | II |
biological activity | 3-(Methylthio) propiacid it is a thiofatty acid that is an intermediate in mammalian Methionine Metabolism in vitro. |